Definitely not, enshitification is real. I’ve gone from someone excited about new products to I don’t trust anything that I didn’t build. We are currently discussing moving our group chat off discord, but I’m biochemist and my circle are similar professions and I’m still learning how to properly host things.
In the before times we used hamachi, but it was hard. Eventually, Skype was born and it was good and easy. It worked like a phone and many StarCraft 2 team games were won. But Skype was corrupted by the many Nigerian princes and hot Ladies who only needed a few dollars to turn your life around. This corruption was then baked so deeply into windows it took registry edits to exorcise it. But all was good was we now had discord which took the ideas of hamachi and Skype and delived a better experience than both.
You’d be surprised how much money gets wasted of stupid projects and acquisitions in biotech because some suit think they understand science better than their R&D team. For analogy sake think about all the stupid shit Microsoft bought and killed or all the chat apps Google created and killed, this going to be Regeneron’s Skype.
If you really want to get your parents sequenced for your own personal use without it going into a database it’ll cost you about $500 per sample (cheaper if you know someone who can extract the DNA for you). You’ll get a set of fastq files for the reads that will cover almost their entire genome that you can then use with public databases or just store for future use. Another option is to sign up for a university study but you’ll have to be comfortable with their data use.
I honestly don’t know what they will do with snp data. These investors and VCs have been running scare peace articles for the last two years to drive the company into bankruptcy so that it could be sold and the data harvested. But I honestly think people are really overestimating the value of a dataset showing how different people are from a standard template. It’s good for ancestry and correlations but people forget they didn’t fully sequence samples. I fully expect the news cycle to change once they figure this out as they try to get people to resubmit DNA for nextgen sequencing, so they can try to salvage their investment.
My Rx580 has basically been on continuously since I bought it in like 2017/18. I used it to mine when I wasn’t gaming until it became unprofitable, then to process sequencing data for my dissertation project while not gaming, and now it’s in my server.
This was almost my gaming PC specs in 2020. Rx580 and 16gb more ram. It’s now my server running jellyfin and immich for my family.
Need more information to properly diagnose. Is this a new issue? Are you using auto build leveling for every print? Have you tried cleaning everything and rerunning the system calibration? A lot of different things can cause similar issues and it’s hard to diagnose from images alone.
I just bought myself a Bambu P1S, after building and modifying ender3s since 2019. I love tinkering and customizing things but it’s nice to have a printer that just works. Its so reliable that my wife can now print her own stuff using the app instead of giving me a list. The only thing I really have to do is change the filaments loaded in the AMS for her. If you have no experience printing I would just get a A1 mini and use it until you run into the limitations.
I have 2 ender 3s, and they were awesome. I learned so much about engineering, gcode, and flashing firmware. I spent so much time fine tuning print parameters and installing mods, and I was able to get decent prints. I moved and picked up a bambu P1S, during a black Friday sale a few years ago. My enders are still packed and my P1S has just worked, giving me prints quality and consistency I only could have dreamed of using my enders. Now, I just need a project to recycle my enders parts into.
Long story short, use teaching tech ender 3 calibration guide, dry your filament, and install auto bed leveling probe that will account for warped build plates. https://teachingtechyt.github.io/calibration.html